LDN--One of the RARE Drugs that Actually Helps Your Body to Heal Itself. An article posted today by Dr. Mercola...9.19.2011


By Dr. Mercola
It is not often that I advocate the use of prescription drugs, but low-dose naltrexone (LDN) is one of those rare exceptions that may hold the promise of helping millions of people with cancer and autoimmune disease.
As a pharmacologically active opioid antagonist, LDN works by blocking opioid receptors, which in turn helps activate your body's immune system.

How LDN Harnesses Your Own Body's Chemistry to Fight Disease

The latest research in Experimental Biology and Medicine just confirmed that LDN does in fact target the opioid growth factor (OGF)/opioid growth factor receptor (OGFr) pathway to inhibit cell proliferation. Previous research by professor Ian S. Zagon of The Pennsylvania State University, who also conducted the Experimental Biology and Medicine study, found that OGF regulates the growth of cancer cells, and all cancer cells use the OGF-OGFr pathway in growth regulation.
It is through this mechanism that LDN is thought to exert its profound inhibitory effect on cancer growth.
Further, LDN also works with your body's immune system through its interactions with your body's endorphins. Though most commonly referenced in relation to you mood, endorphins also play a role in pain relief, immune system regulation, growth of cells and angiogenesis (the growth of blood vessels that feed a tumor).
Typically, LDN is taken at bedtime, which blocks your opioid receptors, as well as the reception of endorphins, for a few hours in the middle of the night. This is believed to up-regulate vital elements of your immune system by increasing your body's production of metenkephalin and endorphins (your natural opioids), hence improving your immune function.
In addition to cancer, LDN has shown promise for the treatment of the following diseases:
Hepatitis CDiabetic neuropathies
LupusDermatomyositis (an inflammatory muscle disease)
Ulcerative colitisMultiple sclerosis
AutismCrohn's disease
Chronic fatigue syndromeAlzheimer's disease
HIV/AIDSHasimoto's thyroiditis
Irritable bowel syndrome (IBS)Parkinson's disease

How can one substance impact so many different diseases? As written on the non-profit Web siteLowDoseNaltrexone.org, which is an excellent resource for more information:
"The disorders listed above all share a particular feature: in all of them, the immune system plays a central role. Low blood levels of endorphins are generally present, contributing to the disease-associated immune deficiencies."

Impressive Results in Cancer Treatment

In 1985, Dr. Bernard Bihari discovered LDN enhanced patients' response to infection with HIV, the virus that causes AIDS. Years later he found that his patients with cancer and autoimmune disease also benefited from LDN.
Dr. Bihari has reportedly treated more than 450 cancer patients with LDN with promising results, including cancers of the bladder, breast, liver, lung, lymph nodes, colon, and rectum. According to Dr. Bihari, nearly a quarter of his patients had at least a 75 percent reduction in tumor size, and nearly 60 percent of his patients demonstrated disease stability. He believes LDN's anti-cancer mechanism is likely due to an increase in the:
  • Number and density of opiate receptors on the tumor cell membranes, making them more responsive to the growth-inhibiting effects of the already present levels of endorphins, which in turn induces apoptosis (cell death) in the cancer cells
  • Absolute numbers of circulating cytotoxic T cells and natural killer cells, as well as killer cell activity
An impressive study released earlier this year exemplifies LDN's potential anti-cancer effects, in this case to treat ovarian cancer.
The study found:
  • LDN administered for six hours every two days reduced DNA synthesis and cell replication in tissue culture
  • Exposure to LDN in combination with cancer drugs had enhanced anti-cancer action
  • Mice with established ovarian tumors treated with LDN had repressed tumor progression by reducing DNA synthesis and angiogenesis -- but not altering cell survival, indicating it is non-toxic
  • LDN combined with a chemotherapy drug, cisplatin, alleaviated the toxicity associated with cisplatin
  • LDN treatment upregulated the expression of the opioid growth factor, which is the only opioid peptide that tends to inhibit cell growth of ovarian cancer cells
Says Dr. Burton M. Berkson, MD, who has attested to achieving phenomenal results with low-dose naltrexone in both cancer patients and those with autoimmune diseases:
"It is difficult for many to believe that one drug can accomplish so many tasks. But LDN does not treat symptoms as most drugs do. It actually works way "upstream" to modulate the basic mechanisms that result in the disease state."

Your Doctor Probably Doesn't Know About Low-Dose Naltrexone

LDN has been an FDA-approved drug for over two decades, conventionally used to treat drug- and alcohol addiction at doses of 50mg to 300mg. Much lower doses (3 to 4.5 mg) are used for LDN's immunomodulating properties as discussed above, but it has not yet been submitted for FDA approval at this low dose. None of the pharmaceutical giants back it, as at an average price of $15 to $40 for a month's supply, the income potential isn't very promising.
This means there are no friendly sales reps visiting your doctor talking about the potential benefits of this drug in very low doses, and as a result very few physicians are aware of LDN. So, if your physician is not familiar with LDN, you will need to bring it up to him or her, or, alternatively, seek a health care provider who is already knowledgeable at using LDN as a form of treatment. There are a number of pharmacies and compounding pharmacies in the United States and Canada that are reliable sources of the compound in low-dose form.

CAUTION: Important LDN Points to Consider if You Use It

  • Avoid slow-release (SR) or timed-release naltrexone. You want to be sure the LDN you receive is in unaltered form that allows you to receive the full dose quickly. Slow-release formulas may not give you the full therapeutic effects.
  • Be aware of inactive fillers. Part of the LDN capsule will contain a "neutral" filler material, however there is some evidence to suggest that calcium carbonate as a filler could interfere with the absorption of LDN. So to be on the safe side, avoid LDN capsules that contain calcium carbonate fillers.
Ideally, if you are interested in using LDN as a potential treatment consult with a knowledgeable health care practitioner who can guide your therapy and also help you find a reliable compounding pharmacy.

6 comments:

  1. wow Tango - i am just catching up on your posts about LDN and i am super-impressed!

    we drink garlic tea with honey (natural antibiotics) every morning and chammomile at night (for sleeping). have you tried chammomile tea? we have had a bad start with our garden this year but give me a chance to get some beautiful, organic, from heirloom seeds chammomile tea up and running and i will send you some - it really does work for insomnia! as well, once i get a decent sized lavender i can send you some of that too...just putting a little sachet under your pillow really works.

    but back to the LDN, we are pretty healthy, physically fit people but based on your results and the results that you have shared, i am going to do some more reading of all of the links that you have provided.

    thanks for all of this eh?

    your friend
    kymber

    ReplyDelete
  2. Hi Kymber...thanks for reading this post and replying. I was beginning to think I scarred everyone off. :)

    I would love to have some of your Chammomile and Lavender, thank you for the offer.

    Glad to hear that you two are keeping healthy...but you know it can prevent things from going wrong, you know?

    ReplyDelete
  3. Tango - from what i have been reading, from the links you have provided in a bazillion posts, plus other links i have found, this stuff is amazing in regards to prevention. and that's why i am so interested. prevention is 99% of the cure.

    i gotta get my hands on some. i sure do hope that it helps with your son.

    as for chammomile and lavender. let me get it grown and i will send you some dried stuff. then next spring, after i check in to how to send live plants to the US, i will see if i can get you some live plants.

    i got your last email, will email in a bit and will get your address. you still have mine eh?

    ReplyDelete
  4. Kymber...yep it's amazing stuff. I'm so glad I found it. I'm sure I would have been pretty miserable by now if I hadn't.
    I look forward to your email...damn, I wish you lived closer. :(

    ReplyDelete
  5. What would we do without our LDN?I am in love with my LDN!

    I'm not a total doctor hater. I have some great docs, but I've met some pretty bad ones too. I was really floored by the comment from my Rheumy when I asked to go on LDN. He had never heard of it, and was not willing to give it to me. He asked me why I would want to take something that is not "proven" when the so called "proven" drugs didn't work for me for my Fibromyalgia. Hmmm!!!! Let me see. Well, for starters, I can take as low of a dose as I need to starting out, and build up to a higher dose, which is going to max out at about 4.5 mg. We are comparing this to 50mg. pills or better of the "proven" drugs? All the "proven" drugs did was make me sick! One threw me into an adrenal crisis with just one pill, and another made me like a drunk, made my hair fall out, and my eyesight horrible! No thanks! My "unproven" (in his book, not mine) LDN, has done way more for me than his "proven" garbage!

    I started my LDN for control of my Fibromyalgia pain. It did that and more! I feel blessed to have been able to start on LDN! I'm reaping more benefits than I even expected!

    ReplyDelete
  6. Grace...thank you for posting. :)

    I love my LDN too and started taking it as a preventative. Much to my surprise I have gotten some really great benefits from taking it all these months.

    My son has some sort of muscle disorder that the doctors can't figure out. They don't think it's Fibro, but can't seem to figure out what it is.

    He started on LDN on September 13th at 1.5 ml. He's now at 2 ml. Saturday he woke up for the first time without pain since December of last year. Even though this only lasted a few hours, it's a good sign that it is working even at such a low dose. I'm hoping that it will really kick in once he's up to 4.5 ml. :)

    ReplyDelete

I know it is only the ramblings and rants of one woman, but I would love to hear from you.

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I was born in Jever, Germany.  My parents immigrated to the United States in 1968.  I became a United States citizen in 2005.
 
Favorite Quote:  Only a free and unrestrained press can effectively expose deception in government.
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I'm a Supporter of Wikileaks, Greenpeace, Amnesty International, The Freestate Project, LDNaware (Low Dose Naltrexone), Non-GMO (Genetically Modified Organisms) Project, Millions Against Monsanto, the NRA (National Rifle Association), GOA (Gun Owners of America),Truth in Labeling, Unconventional Medicine and The Freedom of Choice.